Surgery is the established treatment for patients with primary gastrointestinal stromal tumors gist that are. Tumor del estroma gastrointestinal gist medigraphic. Pdf tumores del estroma gastrointestinal gastrointestinal. Hospital universitario virgen macarena, sevilla, espana. Tumor del estroma gastrointestinal scielo colombia. Gronchi and colleagues studied the role of high dose imatinib in the setting of resistant gists. Seom clinical guideline for gastrointestinal sarcomas gist 2016 article pdf available in clinical and translational oncology 1812 november 2016. Sinais e sintomas dos tumores gastrointestinais gist. Of the 395 patients, the gist genotypes were analyzed and the results showed that 282 71% had cd117 exon 11 mutations, 67 17% had no cd117 or pdgfra mutations, 32 8% had cd117 exon 9 mutations, and 14 4% had both cd117 and pdgfra mutations 28. Clinically, this type of gist usually begin with symptoms like upper gastrointestinal bleeding, followed by abdominal chronic pain, and when the tumor size is considerably big it could be detected during abdominal manual exploration.